Polyethylene Glycol-Conjugated L-Asparaginase Versus Native L-Asparaginase In Combination With Standard Agents For Children With Acute Lymphoblastic Leukemia In Second Bone Marrow Relapse: A Children’s Oncology Group Study (Pog 8866)

Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To overcome this problem, native E. coli L-asparaginase was conjugated to polyethylene glycol to formulate PEG-L-asparaginase, a preparation with decreased immunogenicity and increased...

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Autori principali: Kurtzberg, Joanne, Asselin, Barbara, Bernstein, Mark, Buchanan, George R., Pollock, Brad H., Camitta, Bruce M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557823/
https://ncbi.nlm.nih.gov/pubmed/22042277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPH.0b013e31822d4d4e
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