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Polyethylene Glycol-Conjugated L-Asparaginase Versus Native L-Asparaginase In Combination With Standard Agents For Children With Acute Lymphoblastic Leukemia In Second Bone Marrow Relapse: A Children’s Oncology Group Study (Pog 8866)
Administration of L-asparaginase is limited by hypersensitivity reactions mediated by anti-asparaginase antibodies. To overcome this problem, native E. coli L-asparaginase was conjugated to polyethylene glycol to formulate PEG-L-asparaginase, a preparation with decreased immunogenicity and increased...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557823/ https://ncbi.nlm.nih.gov/pubmed/22042277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPH.0b013e31822d4d4e |
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