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Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes
Chronic exposure to elevated levels of manganese (Mn(2+)) causes neuronal injury and inflammatory activation of glia. Astrocytes selectively accumulate Mn(2+), which inhibits mitochondrial respiration and increases production of reactive oxygen species. We previously reported that sub-acute exposure...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557543/ https://ncbi.nlm.nih.gov/pubmed/23131343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2012.10.014 |
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