Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma

Glioblastoma multiforme (GBM) is a highly invasive and chemoradioresistant brain malignancy. Temozolomide (TMZ), a DNA-alkylating agent, is effective against GBM and has become the standard first-line drug. However, the mechanism by which TMZ regulates the progression of GBM remains elusive. Here, w...

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Bibliografische gegevens
Hoofdauteurs: Yamaki, Tomohiro, Suenaga, Yusuke, Iuchi, Toshihiko, Alagu, Jennifer, Takatori, Atsushi, Itami, Makiko, Araki, Akinobu, Ohira, Miki, Inoue, Masahiro, Kageyama, Hajime, Yokoi, Sana, Saeki, Naokatsu, Nakagawara, Akira
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3557454/
https://ncbi.nlm.nih.gov/pubmed/23362460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01160
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