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Voltage regulates adrenergic receptor function
The present study demonstrates that agonist-mediated activation of α2A adrenergic receptors (α(2A)AR) is voltage-dependent. By resolving the kinetics of conformational changes of α(2A)AR at defined membrane potentials, we show that negative membrane potentials in the physiological range promote agon...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3557066/ https://ncbi.nlm.nih.gov/pubmed/23297214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1212656110 |
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