Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to lymphoid organs by migrating along stromal scaffolds that display the glycoprotein podoplanin (PDPN). PDPN is expressed by lymphatic endothelial and fibroblastic reticular cells and promotes blood-lymph separation...

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Main Authors: Acton, Sophie E., Astarita, Jillian L., Malhotra, Deepali, Lukacs-Kornek, Veronika, Franz, Bettina, Hess, Paul R., Jakus, Zoltan, Kuligowski, Michael, Fletcher, Anne L., Elpek, Kutlu G., Bellemare-Pelletier, Angelique, Sceats, Lindsay, Reynoso, Erika D., Gonzalez, Santiago F., Graham, Daniel B., Chang, Jonathan, Peters, Anneli, Woodruff, Matthew, Kim, Young-A., Swat, Wojciech, Morita, Takashi, Kuchroo, Vijay, Carroll, Michael C., Kahn, Mark L., Wucherpfennig, Kai W., Turley, Shannon J.
Format: Artigo
Language:Inglês
Published: Cell Press 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556784/
https://ncbi.nlm.nih.gov/pubmed/22884313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.05.022
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