Kynurenine is a novel endothelium-derived relaxing factor produced during inflammation

Control of blood vessel tone is central to vascular homeostasis. Here, we show that metabolism of tryptophan to kynurenine by indoleamine 2,3-dioxygenase (IDO) expressed in endothelial cells contributes to arterial vessel relaxation and the control of blood pressure. Infection of mice with malarial...

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Autors principals: Wang, Yutang, Liu, Hanzhong, McKenzie, Gavin, Witting, Paul K, Stasch, Johannes-Peter, Hahn, Michael, Changsirivathanathamrong, Dechaboon, Wu, Ben J, Ball, Helen J, Thomas, Shane R, Kapoor, Vimal, Celermajer, David S, Mellor, Andrew L, Keaney, John F, Hunt, Nicholas H, Stocker, Roland
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556275/
https://ncbi.nlm.nih.gov/pubmed/20190767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2092
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