Agouti C57BL/6N embryonic stem cells for mouse genetic resources

We report the characterization of a highly germline competent C57BL/6N mouse embryonic stem cell line, JM8. To simplify breeding schemes, the dominant Agouti coat color gene was restored in JM8 cells by targeted repair of the C57BL/6 nonagouti mutation. These cells provide a robust foundation for la...

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Bibliographic Details
Main Authors: Pettitt, Stephen J., Liang, Qi, Rairdan, Xin Y., Moran, Jennifer L., Prosser, Haydn M., Beier, David R., Lloyd, Kent, Bradley, Allan, Skarnes, William C.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3555078/
https://ncbi.nlm.nih.gov/pubmed/19525957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1342
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