Disruption of Ionic Interactions between the Nucleotide Binding Domain 1 (NBD1) and Middle (M) Domain in Hsp100 Disaggregase Unleashes Toxic Hyperactivity and Partial Independence from Hsp70

Hsp100 chaperones cooperate with the Hsp70 chaperone system to disaggregate and reactivate heat-denatured aggregated proteins to promote cell survival after heat stress. The homology models of Hsp100 disaggregases suggest the presence of a conserved network of ionic interactions between the first nu...

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Main Authors: Lipińska, Natalia, Ziętkiewicz, Szymon, Sobczak, Alicja, Jurczyk, Agnieszka, Potocki, Wojciech, Morawiec, Ewa, Wawrzycka, Aleksandra, Gumowski, Krzysztof, Ślusarz, Magdalena, Rodziewicz-Motowidło, Sylwia, Chruściel, Elżbieta, Liberek, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554950/
https://ncbi.nlm.nih.gov/pubmed/23233670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.387589
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