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Cathepsin H Mediates the Processing of Talin and Regulates Migration of Prostate Cancer Cells
The cytoskeletal protein talin, an actin- and β-integrin tail-binding protein, plays an important role in cell migration by promoting integrin activation and focal adhesion formation. Here, we show that talin is a substrate for cathepsin H (CtsH), a lysosomal cysteine protease with a strong aminopep...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554893/ https://ncbi.nlm.nih.gov/pubmed/23204516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.436394 |
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