Citicoline induces angiogenesis improving survival of vascular/human brain microvessel endothelial cells through pathways involving ERK1/2 and insulin receptor substrate-1

BACKGROUND: Citicoline is one of the neuroprotective agents that have been used as a therapy in stroke patients. There is limited published data describing the mechanisms through which it acts. METHODS: We used in vitro angiogenesis assays: migration, proliferation, differentiation into tube-like st...

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Autores principales: Krupinski, Jerzy, Abudawood, Manal, Matou-Nasri, Sabine, Al-Baradie, Raid, Petcu, Eugen Bogdan, Justicia, Carlos, Planas, Anna, Liu, Donghui, Rovira, Norma, Grau-Slevin, Marta, Secades, Julio, Slevin, Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554547/
https://ncbi.nlm.nih.gov/pubmed/23227823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2045-824X-4-20
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