Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques

The melanocortin-4 receptor (MC4R) is well recognized as an important mediator of body weight homeostasis. Activation of MC4R causes dramatic weight loss in rodent models, and mutations in human are associated with obesity. This makes MC4R a logical target for pharmacological therapy for the treatme...

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Hlavní autoři: Kievit, Paul, Halem, Heather, Marks, Daniel L., Dong, Jesse Z., Glavas, Maria M., Sinnayah, Puspha, Pranger, Lindsay, Cowley, Michael A., Grove, Kevin L., Culler, Michael D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2013
Témata:
Obesity Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554387/
https://ncbi.nlm.nih.gov/pubmed/23048186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0598
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