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The prolyl-isomerase Pin1 activates the mitochondrial death program of p53
In response to intense stress, the tumor protein p53 (p53) tumor suppressor rapidly mounts a direct mitochondrial death program that precedes transcription-mediated apoptosis. By eliminating severely damaged cells, this pathway contributes to tumor suppression as well as to cancer cell killing induc...
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| Главные авторы: | , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3554345/ https://ncbi.nlm.nih.gov/pubmed/22935610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.112 |
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