A Large-Scale Chemical Screen for Regulators of the Arginase 1 Promoter Identifies the Soy Isoflavone Daidzeinas a Clinically Approved Small Molecule That Can Promote Neuronal Protection or Regeneration via a cAMP-Independent Pathway

An ideal therapeutic for stroke or spinal cord injury should promote survival and regeneration in the CNS. Arginase 1 (Arg1) has been shown to protect motor neurons from trophic factor deprivation and allow sensory neurons to overcome neurite outgrowth inhibition by myelin proteins. To identify smal...

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Main Authors: Ma, Thong C., Campana, Aline, Lange, Philipp S., Lee, Hsin-Hwa, Banerjee, Kasturi, Bryson, J. Barney, Mahishi, Lata, Alam, Shabnam, Giger, Roman J., Barnes, Stephen, Morris, Sidney M., Willis, Dianna E., Twiss, Jeffrey L., Filbin, Marie T., Ratan, Rajiv R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554247/
https://ncbi.nlm.nih.gov/pubmed/20071539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5266-09.2010
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