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A Quantitative Signaling Screen Identifies CARD11 Mutations in the CARD and LATCH Domains That Induce Bcl10 Ubiquitination and Human Lymphoma Cell Survival

Antigen receptor signaling to NF-κB, essential for normal lymphocyte activation, is dysregulated in several types of lymphoma. During normal signaling, the multidomain adapter CARD11 transitions from a closed, inactive state to an open, active scaffold that assembles a multiprotein complex, leading...

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Detalhes bibliográficos
Main Authors: Chan, Waipan, Schaffer, Thomas B., Pomerantz, Joel L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554118/
https://ncbi.nlm.nih.gov/pubmed/23149938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00850-12
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