Human T Cell Leukemia Virus Type 2 Tax-Mediated NF-κB Activation Involves a Mechanism Independent of Tax Conjugation to Ubiquitin and SUMO

Permanent activation of the NF-κB pathway by the human T cell leukemia virus type 1 (HTLV-1) Tax (Tax1) viral transactivator is a key event in the process of HTLV-1-induced T lymphocyte immortalization and leukemogenesis. Although encoding a Tax transactivator (Tax2) that activates the canonical NF-...

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Autores principales: Journo, Chloé, Bonnet, Amandine, Favre-Bonvin, Arnaud, Turpin, Jocelyn, Vinera, Jennifer, Côté, Emilie, Chevalier, Sébastien Alain, Kfoury, Youmna, Bazarbachi, Ali, Pique, Claudine, Mahieux, Renaud
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Transformation and Oncogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3554075/
https://ncbi.nlm.nih.gov/pubmed/23135727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01792-12
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