Transcriptional Regulation of the nadA Gene in Neisseria meningitidis Impacts the Prediction of Coverage of a Multicomponent Meningococcal Serogroup B Vaccine

The NadA adhesin is a major component of 4CMenB, a novel vaccine to prevent meningococcus serogroup B (MenB) infection. Under in vitro growth conditions, nadA is repressed by the regulator NadR and poorly expressed, resulting in inefficient killing of MenB strains by anti-NadA antibodies. Interestin...

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Main Authors: Fagnocchi, Luca, Biolchi, Alessia, Ferlicca, Francesca, Boccadifuoco, Giuseppe, Brunelli, Brunella, Brier, Sébastien, Norais, Nathalie, Chiarot, Emiliano, Bensi, Giuliano, Kroll, J. Simon, Pizza, Mariagrazia, Donnelly, John, Giuliani, Marzia Monica, Delany, Isabel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553804/
https://ncbi.nlm.nih.gov/pubmed/23230289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01085-12
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