Rifaximin Resistance in Escherichia coli Associated with Inflammatory Bowel Disease Correlates with Prior Rifaximin Use, Mutations in rpoB, and Activity of Phe-Arg-β-Naphthylamide-Inhibitable Efflux Pumps

Escherichia coli is implicated in the pathogenesis of inflammatory bowel disease (IBD). Rifaximin, a nonabsorbable derivative of rifampin effective against E. coli, improves symptoms in mild-to-moderate IBD. However, rifaximin resistance can develop in a single step in vitro. We examined the prevale...

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Bibliografiske detaljer
Main Authors: Kothary, Vishesh, Scherl, Ellen J., Bosworth, Brian, Jiang, Zhi-Dong, DuPont, Herbert L., Harel, Josee, Simpson, Kenneth W., Dogan, Belgin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553721/
https://ncbi.nlm.nih.gov/pubmed/23183443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02163-12
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