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Cis and Trans Regulatory Mechanisms Control AP2-Mediated B Cell Receptor Endocytosis via Select Tyrosine-Based Motifs

Following antigen recognition, B cell receptor (BCR)-mediated endocytosis is the first step of antigen processing and presentation to CD4+ T cells, a crucial component of the initiation and control of the humoral immune response. Despite this, the molecular mechanism of BCR internalization is poorly...

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Detalhes bibliográficos
Main Authors: Busman-Sahay, Kathleen, Drake, Lisa, Sitaram, Anand, Marks, Michael, Drake, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553015/
https://ncbi.nlm.nih.gov/pubmed/23372794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054938
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