Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Non-transgenic Mice

Parkinson’s disease is characterized by abundant α-Synuclein (α-Syn) neuronal inclusions known as Lewy-bodies and Lewy-neurites, and the massive loss of midbrain dopamine neurons. However, a cause-and-effect relationship between Lewy inclusion formation and neurodegeneration remains unclear. Here we...

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Bibliografiske detaljer
Main Authors: Luk, Kelvin C., Kehm, Victoria, Carroll, Jenna, Zhang, Bin, O’Brien, Patrick, Trojanowski, John Q., Lee, Virginia M.-Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552321/
https://ncbi.nlm.nih.gov/pubmed/23161999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1227157
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