An Overlapping Protein-Coding Region In Influenza A Virus Segment 3 Modulates the Host Response

Influenza A virus (IAV) infection leads to variable and imperfectly understood pathogenicity. We report that segment 3 of the virus contains a second open reading frame (‘X-ORF’), accessed via ribosomal frameshifting. The frameshift product, termed PA-X, comprises the endonuclease domain of the vira...

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Hauptverfasser: Jagger, B. W., Wise, H. M., Kash, J. C., Walters, K.-A., Wills, N. M., Xiao, Y.-L., Dunfee, R. L., Schwartzman, L. M., Ozinsky, A., Bell, G. L., Dalton, R. M., Lo, A., Efstathiou, S., Atkins, J. F., Firth, A. E., Taubenberger, J. K., Digard, P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552242/
https://ncbi.nlm.nih.gov/pubmed/22745253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1222213
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