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Selective Targeting of the Repressive Transcription Factors YY1 and cMyc to Disrupt Quiescent Human Immunodeficiency Viruses

Quiescent HIV-1 infection of resting CD4(+) T cells is an obstacle to eradication of HIV-1 infection. These reservoirs are maintained, in part, by repressive complexes that bind to the HIV-1 long terminal repeat (LTR) and recruit histone deacetylases (HDACs). cMyc and YY1 are two transcription facto...

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Bibliografiske detaljer
Main Authors: Barton, Kirston, Margolis, David
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552162/
https://ncbi.nlm.nih.gov/pubmed/22866663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2012.0227
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