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Equilibrium-dependent bisphosphonate interaction with crystalline bone mineral explains the pharmacokinetics and osteonecrosis of the jaw in rats
Bisphosphonates (BPs) are chemically stable analogs of pyrophosphate exhibiting strong affinity to bone and have been used for the treatment of diseases characterized by excessive bone resorption. Contrary to the widely accepted BP accumulation model in bone after repeated applications, we report he...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3552081/ https://ncbi.nlm.nih.gov/pubmed/23219943 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2012.11.030 |
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