Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated microRNA Circuits

The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell lineage-specific transcription factors. Here we report that repression of a single RNA binding protein PTB, which occurs during normal brain development via the action of miR-124, is suff...

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Bibliografiske detaljer
Main Authors: Xue, Yuanchao, Ouyang, Kunfu, Huang, Jie, Zhou, Yu, Ouyang, Hong, Li, Hairi, Wang, Gang, Wu, Qijia, Wei, Chaoliang, Bi, Yanzhen, Jiang, Li, Cai, Zhiqiang, Sun, Hui, Zhang, Kang, Zhang, Yi, Chen, Ju, Fu, Xiang-Dong
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3552026/
https://ncbi.nlm.nih.gov/pubmed/23313552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.11.045
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