Fc gamma receptor IIIa polymorphisms in advanced colorectal cancer patients correlated with response to anti-EGFR antibodies and clinical outcome

BACKGROUND: Anti-EGFR monoclonal antibodies have shown efficacy in the treatment of metastatic colorectal cancer (mCRC). One of the mechanism is the antibody-dependent cell-mediated cytotoxicity (ADCC) in which Fc region of the antibody binds to the Fc gamma receptors (FcγR) expressed by immune cell...

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Autores principales: Calemma, Rosa, Ottaiano, Alessandro, Trotta, Anna Maria, Nasti, Guglielmo, Romano, Carmela, Napolitano, Maria, Galati, Domenico, Borrelli, Pasquale, Zanotta, Serena, Cassata, Antonino, Castello, Giuseppe, Iaffaioli, Vincenzo Rosario, Scala, Stefania
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551834/
https://ncbi.nlm.nih.gov/pubmed/23171437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-232
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