NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug

BACKGROUND: Most DNA-damaging chemotherapeutic agents activate the transcription factor nuclear factor κB (NF-κB). However, NF-κB activation can either protect from or contribute to the growth suppressive effects of the agent. We previously showed that the DNA-methylating drug temozolomide (TMZ) act...

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Detalhes bibliográficos
Main Authors: Caporali, Simona, Levati, Lauretta, Graziani, Grazia, Muzi, Alessia, Atzori, Maria Grazia, Bonmassar, Enzo, Palmieri, Giuseppe, Ascierto, Paolo A, D’Atri, Stefania
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551789/
https://ncbi.nlm.nih.gov/pubmed/23259744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-252
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