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Exploring Key Orientations at Protein-protein Interfaces with Small Molecule Probes
[Image: see text] Small molecule probes that selectively perturb protein-protein interactions (PPIs) are pivotal to biomedical science, but their discovery is challenging. We hypothesized conformational resemblance of semi-rigid scaffolds expressing amino acid side-chains to PPI-interface regions co...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3551583/ https://ncbi.nlm.nih.gov/pubmed/23270593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3067258 |
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