Exploring Key Orientations at Protein-protein Interfaces with Small Molecule Probes

[Image: see text] Small molecule probes that selectively perturb protein-protein interactions (PPIs) are pivotal to biomedical science, but their discovery is challenging. We hypothesized conformational resemblance of semi-rigid scaffolds expressing amino acid side-chains to PPI-interface regions co...

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Bibliographic Details
Main Authors: Ko, Eunhwa, Raghuraman, Arjun, Perez, Lisa M., Ioerger, Thomas R., Burgess, Kevin
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551583/
https://ncbi.nlm.nih.gov/pubmed/23270593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3067258
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