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Synthesis and Characterization of the 47-Residue Heterodimeric Antimicrobial Peptide Distinctin, Featuring Directed Disulfide Bridge Formation

Distinctin, a 47-residue heterodimeric peptide with potent antimicrobial activity, comprises two monomeric units linked covalently by a disulfide bond between Cys19 from the 22-residue A chain and Cys23 from the 25-residue B chain. Previous synthetic strategies involved assemblies of the two individ...

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מידע ביבליוגרפי
Main Authors: Mullen, Daniel G., Verardi, Raffaello, Porcelli, Fernando, Scaloni, Andrea, Barany, George, Veglia, Gianluigi
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551542/
https://ncbi.nlm.nih.gov/pubmed/23203692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22087
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