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Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer’s disease

Scanning the entire genome in search of variants related to imaging phenotypes holds great promise in elucidating the genetic etiology of neurodegenerative disorders. Here we discuss the application of a penalized multivariate model, sparse reduced-rank regression (sRRR), for the genome-wide detecti...

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Main Authors: Vounou, Maria, Janousova, Eva, Wolz, Robin, Stein, Jason L., Thompson, Paul M., Rueckert, Daniel, Montana, Giovanni
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551466/
https://ncbi.nlm.nih.gov/pubmed/22209813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2011.12.029
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