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Sparse reduced-rank regression detects genetic associations with voxel-wise longitudinal phenotypes in Alzheimer’s disease

Scanning the entire genome in search of variants related to imaging phenotypes holds great promise in elucidating the genetic etiology of neurodegenerative disorders. Here we discuss the application of a penalized multivariate model, sparse reduced-rank regression (sRRR), for the genome-wide detecti...

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Bibliografiske detaljer
Main Authors: Vounou, Maria, Janousova, Eva, Wolz, Robin, Stein, Jason L., Thompson, Paul M., Rueckert, Daniel, Montana, Giovanni
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551466/
https://ncbi.nlm.nih.gov/pubmed/22209813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroimage.2011.12.029
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