Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function

Cytokine-activated STAT proteins dimerize and bind to high-affinity motifs, and N-terminal domain-mediated oligomerization of dimers allows tetramer formation and binding to low-affinity tandem motifs, but the functions of dimers versus tetramers are unknown. We generated Stat5a-Stat5b double knock-...

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Detalhes bibliográficos
Main Authors: Lin, Jian-Xin, Li, Peng, Liu, Delong, Jin, Hyun Tak, He, Jianping, Rasheed, Mohammed Ata Ur, Rochman, Yrina, Wang, Lu, Cui, Kairong, Liu, Chengyu, Kelsall, Brian L., Ahmed, Rafi, Leonard, Warren J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551341/
https://ncbi.nlm.nih.gov/pubmed/22520852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.02.017
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