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Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease

Huntington's disease (HD) is a neuropsychiatric disorder characterized by choreiform movement of the limbs, cognitive disability, psychosis and dementia. It is invariably associated with an abnormally long CAG expansion within the IT15 gene on human chromosome 4. Although the mutant huntingtin...

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Main Authors: Baiamonte, Brandon A., Lee, Franklin A., Brewer, Steve T., Spano, Daniela, LaHoste, Gerald J.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549908/
https://ncbi.nlm.nih.gov/pubmed/23349722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053606
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