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Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia

DNA methylation is linked to homocysteine metabolism through the generation of S-adenosylmethionine (AdoMet) and S-Adenosylhomocysteine (AdoHcy). The ratio of AdoMet/AdoHcy is often considered an indicator of tissue methylation capacity. The goal of this study is to determine the relationship of tis...

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Detalhes bibliográficos
Main Authors: Glier, Melissa B., Ngai, Ying F., Sulistyoningrum, Dian C., Aleliunas, Rika E., Bottiglieri, Teodoro, Devlin, Angela M.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549880/
https://ncbi.nlm.nih.gov/pubmed/23221482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.23063
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