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Caveolae Optimize Tissue Factor-Factor VIIa Inhibitory Activity of Cell Surface Associated Tissue Factor Pathway Inhibitor

Tissue factor pathway inhibitor (TFPI) is an anticoagulant protein that prevents intravascular coagulation through inhibition of factor Xa (fXa) and the tissue factor (TF)-factor VIIa complex (TF-fVIIa). Localization of TFPI within caveolae enhances its anticoagulant activity. To further define how...

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Detalhes bibliográficos
Main Authors: Maroney, Susan A., Ellery, Paul E., Wood, Jeremy P., Ferrel, Josephine P., Bonesho, Catherine E., Mast, Alan E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549619/
https://ncbi.nlm.nih.gov/pubmed/22239091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111994
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