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Anthranilate phosphoribosyl transferase (TrpD) generates phosphoribosylamine for thiamine synthesis from enamines and phosphoribosyl pyrophosphate

Anthranilate phosphoribosyl transferase (TrpD) has been well characterized for its role in the tryptophan biosynthetic pathway. Here, we characterized a new reaction catalyzed by TrpD that resulted in the formation of the purine/thiamine intermediate metabolite phosphoribosylamine (PRA). The data sh...

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Detalhes bibliográficos
Main Authors: Lambrecht, Jennifer A., Downs, Diana M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549051/
https://ncbi.nlm.nih.gov/pubmed/23101964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300364k
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