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Evolving the [Myoglobin, Cytochrome b(5)] Complex from Dynamic Toward Simple Docking: Charging the Electron-Transfer Reactive Patch

We describe photo-initiated electron transfer (ET) from a suite of Zn-substituted myoglobin (1Mb) variants to cytochrome b(5) (b(5)). An electrostatic interface redesign strategy has led to the introduction of positive charges in the vicinity of the heme edge through D/E → K charge-reversal mutation...

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書誌詳細
主要な著者: Trana, Ethan N., Nocek, Judith M., Knutson, Amanda K., Hoffman, Brian M.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3549022/
https://ncbi.nlm.nih.gov/pubmed/23067206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301134f
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