Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy that resists current treatments. To test epigenetic therapy against this cancer, we used the DNA demethylating drug 5-aza-2′-deoxycytidine (DAC) in an aggressive mouse model of stromal rich PDAC (KPC-Brca1 mice). In untreated tumors, we...

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Hauptverfasser: Shakya, Reena, Gonda, Tamas, Quante, Michael, Salas, Martha, Kim, Samuel, Brooks, Jenna, Hirsch, Steffen, Davies, Justine, Cullo, Angelica, Olive, Kenneth, Wang, Timothy C., Szabolcs, Matthias, Tycko, Benjamin, Ludwig, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548986/
https://ncbi.nlm.nih.gov/pubmed/23204224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1880
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