Oroxylin A Inhibits Hemolysis via Hindering the Self-Assembly of α-Hemolysin Heptameric Transmembrane Pore

Alpha-hemolysin (α-HL) is a self-assembling, channel-forming toxin produced by most Staphylococcus aureus strains as a 33.2-kDa soluble monomer. Upon binding to a susceptible cell membrane, the monomer self-assembles to form a 232.4-kDa heptamer that ultimately causes host cell lysis and death. Cons...

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Hauptverfasser: Dong, Jing, Qiu, Jiazhang, Zhang, Yu, Lu, Chongjian, Dai, Xiaohan, Wang, Jianfeng, Li, Hongen, Wang, Xin, Tan, Wei, Luo, Mingjing, Niu, Xiaodi, Deng, Xuming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547825/
https://ncbi.nlm.nih.gov/pubmed/23349625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002869
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