Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach

BACKGROUND: Torcetrapib, a cholesteryl ester transfer protein (CETP) inhibitor which raises high-density lipoprotein (HDL) cholesterol and reduces low-density lipoprotein (LDL) cholesterol level, has been documented to increase mortality and cardiac events associated with adverse effects. However, i...

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Hlavní autoři: Fan, Shengjun, Geng, Qiang, Pan, Zhenyu, Li, Xin, Tie, Lu, Pan, Yan, Li, Xuejun
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547811/
https://ncbi.nlm.nih.gov/pubmed/23228038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-152
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