An inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia

To define the mutation spectrum in non-Down syndrome acute megkaryoblastic leukemia (non-DS-AMKL), we performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated our findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL leukemia...

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Detalhes bibliográficos
Main Authors: Gruber, Tanja A., Gedman, Amanda Larson, Zhang, Jinghui, Koss, Cary S., Marada, Suresh, Ta, Huy Q., Chen, Shann-Ching, Su, Xiaoping, Ogden, Stacey K., Dang, Jinjun, Wu, Gang, Gupta, Vedant, Andersson, Anna K., Pounds, Stanley, Shi, Lei, Easton, John, Barbato, Michael I., Mulder, Heather L., Manne, Jayanthi, Wang, Jianmin, Rusch, Michael, Ranade, Swati, Ganti, Ramapriya, Parker, Matthew, Ma, Jing, Radtke, Ina, Ding, Li, Cazzaniga, Giovanni, Biondi, Andrea, Kornblau, Steven M., Ravandi, Farhad, Kantarjian, Hagop, Nimer, Stephen D., Döhner, Konstanze, Döhner, Hartmut, Ley, Timothy J., Ballerini, Paola, Shurtleff, Sheila, Tomizawa, Daisuke, Adachi, Souichi, Hayashi, Yasuhide, Tawa, Akio, Shih, Lee-Yung, Liang, Der-Cherng, Rubnitz, Jeffrey E., Pui, Ching-Hon, Mardis, Elaine R, Wilson, Richard K, Downing, James R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547667/
https://ncbi.nlm.nih.gov/pubmed/23153540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.10.007
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