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Signaling by SHH Rescues Facial Defects Following Blockade in the Brain
BACKGROUND: The Frontonasal Ectodermal Zone (FEZ) is a signaling center in the face that expresses Sonic hedgehog (Shh) and regulates patterned growth of the upper jaw. Blocking SHH in the forebrain blocks Shh expression in the FEZ and creates malformations resembling holoprosencephaly (HPE), while...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3547623/ https://ncbi.nlm.nih.gov/pubmed/22275045 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.23726 |
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