Signaling by SHH Rescues Facial Defects Following Blockade in the Brain

BACKGROUND: The Frontonasal Ectodermal Zone (FEZ) is a signaling center in the face that expresses Sonic hedgehog (Shh) and regulates patterned growth of the upper jaw. Blocking SHH in the forebrain blocks Shh expression in the FEZ and creates malformations resembling holoprosencephaly (HPE), while...

Full description

Saved in:
Bibliographic Details
Main Authors: Chong, H. Jonathan, Young, Nathan M., Hu, Diane, Jeong, Juhee, McMahon, Andrew P., Hallgrimsson, Benedikt, Marcucio, Ralph S.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547623/
https://ncbi.nlm.nih.gov/pubmed/22275045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.23726
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items