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Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

MicroRNAs regulate gene expression through deadenylation, repression and mRNA decay. However, the contribution of each mechanism in non-steady-state situations remains unclear. We monitored the impact of miR-430 on ribosome occupancy of endogenous mRNAs in wild type and dicer mutants lacking mature...

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Detalhes bibliográficos
Main Authors: Bazzini, Ariel A., Lee, Miler T., Giraldez, Antonio J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547538/
https://ncbi.nlm.nih.gov/pubmed/22422859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1215704
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