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Protein S-glutathionylation enhances Ca(2+)-induced Ca(2+) release via the IP(3) receptor in cultured aortic endothelial cells

In non-excitable cells, thiol-oxidizing agents have been shown to evoke oscillations in cytosolic free Ca(2+) concentration ([Ca(2+)](i)) by increasing the sensitivity of the inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) to IP(3). Although thiol modification of the IP(3)R is implicated in t...

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Detalhes bibliográficos
Main Authors: Lock, Jeffrey T, Sinkins, William G, Schilling, William P
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547261/
https://ncbi.nlm.nih.gov/pubmed/22855054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.230656
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