Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration

BACKGROUND: The recruitment and activation of inflammatory cells is thought to exacerbate photoreceptor death in retinal degenerative conditions such as age-related macular degeneration (AMD). We investigated the role of Müller cell-derived chemokine (C-C motif) ligand (Ccl)2 expression on monocyte/...

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Detaylı Bibliyografya
Asıl Yazarlar: Rutar, Matt, Natoli, Riccardo, Provis, Jan M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2012
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546872/
https://ncbi.nlm.nih.gov/pubmed/22992301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-221
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