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Effects of Schizonepetin on Activity and mRNA Expression of Cytochrome P450 Enzymes in Rats

The aim of this study was to find out whether Schizonepetin influences the pharmacokinetics of the main substrates drugs of CYP1A2, CYP3A1/2, CYP2E1, CYP2C19 and CYP2D6 in rats; the influence on the levels of CYP mRNA was also studied. Phenacetin, dapsone, chlorzoxazone, omeprazole and metoprolol we...

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Main Authors: Bao, Beihua, Geng, Ting, Cao, Yudan, Yao, Weifeng, Zhang, Li, Ding, Anwei
Formato: Artigo
Idioma:Inglês
Publicado: Molecular Diversity Preservation International (MDPI) 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546736/
https://ncbi.nlm.nih.gov/pubmed/23235327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms131217006
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