A Recombinant Immunotoxin Against the Tumor-Associated Antigen Mesothelin Reengineered for High Activity, Low Off-Target Toxicity, and Reduced Antigenicity

SS1P is a recombinant immunotoxin (RIT) engineered for the targeted elimination of malignant cells that express the tumor-associated antigen mesothelin. It is comprised of an anti-mesothelin antibody Fv linked to a cytotoxic fragment of Pseudomonas exotoxin A (PE) that includes domains II and III of...

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Bibliographic Details
Main Authors: Weldon, John E., Xiang, Laiman, Zhang, Jingli, Beers, Richard, Walker, Dawn A., Onda, Masanori, Hassan, Raffit, Pastan, Ira
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546136/
https://ncbi.nlm.nih.gov/pubmed/23136186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0336
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