Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis

Enteritis caused by Clostridium difficile toxin (Tx) is a nosocomial disease of increasing clinical concern, but the local mediators of C. difficile TxA inflammation are unknown. The potent vasodilator calcitonin gene-related peptide mediates neurogenic inflammation via the calcitonin receptor-like...

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Autors principals: Bhargava, Aditi, Clifton, Matthew S., Mhaske, Pallavi, Liao, Min, Pothoulakis, Charalabos, Leeman, Susan E., Grady, Eileen F.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545755/
https://ncbi.nlm.nih.gov/pubmed/23267070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219733110
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