A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

The ribonucleoprotein telomerase synthesizes telomeric DNA by copying an intrinsic RNA template. In most cancer cells, telomerase is highly activated. Here we report a telomerase-based antitumor strategy: expression of mutant-template telomerase RNAs in human cancer cells. We expressed mutant-templa...

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Autors principals: Kim, Moses M., Rivera, Melissa A., Botchkina, Inna L., Shalaby, Refaat, Thor, Ann D., Blackburn, Elizabeth H.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC35454/
https://ncbi.nlm.nih.gov/pubmed/11438744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131211098
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