A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation

The ribonucleoprotein telomerase synthesizes telomeric DNA by copying an intrinsic RNA template. In most cancer cells, telomerase is highly activated. Here we report a telomerase-based antitumor strategy: expression of mutant-template telomerase RNAs in human cancer cells. We expressed mutant-templa...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kim, Moses M., Rivera, Melissa A., Botchkina, Inna L., Shalaby, Refaat, Thor, Ann D., Blackburn, Elizabeth H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35454/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11438744/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.131211098
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