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A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
The ribonucleoprotein telomerase synthesizes telomeric DNA by copying an intrinsic RNA template. In most cancer cells, telomerase is highly activated. Here we report a telomerase-based antitumor strategy: expression of mutant-template telomerase RNAs in human cancer cells. We expressed mutant-templa...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC35454/ https://ncbi.nlm.nih.gov/pubmed/11438744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.131211098 |
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