Synthesis and preclinical evaluation of a new C-6 alkylated pyrimidine derivative as a PET imaging agent for HSV1-tk gene expression

[(18)F]FHOMP (6-((1-[(18)F]-fluoro-3-hydroxypropan-2-yloxy)methyl)-5-methylpyrimidine-2,4(1H,3H)-dione), a C-6 substituted pyrimidine derivative, has been synthesized and evaluated as a potential PET agent for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression. [(18)F]FHO...

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Detalhes bibliográficos
Main Authors: Müller, Ursina, Ross, Tobias L, Ranadheera, Charlene, Slavik, Roger, Müller, Adrienne, Born, Mariana, Trauffer, Evelyn, Sephton, Selena Milicevic, Scapozza, Leonardo, Krämer, Stefanie D, Ametamey, Simon M
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545364/
https://ncbi.nlm.nih.gov/pubmed/23342302
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