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Novel Selective and Irreversible Mosquito Acetylcholinesterase Inhibitors for Controlling Malaria and Other Mosquito-Borne Diseases

We reported previously that insect acetylcholinesterases (AChEs) could be selectively and irreversibly inhibited by methanethiosulfonates presumably through conjugation to an insect-specific cysteine in these enzymes. However, no direct proof for the conjugation has been published to date, and doubt...

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Detalhes bibliográficos
Main Authors: Dou, Dengfeng, Park, Jewn Giew, Rana, Sandeep, Madden, Benjamin J., Jiang, Haobo, Pang, Yuan-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3545233/
https://ncbi.nlm.nih.gov/pubmed/23323211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01068
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